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G protein-coupled receptor kinase
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G protein-coupled receptor kinase : ウィキペディア英語版
G protein-coupled receptor kinase

G protein-coupled receptor kinases (GRKs, GPCRKs) are a family of protein kinases that regulate the activity of G protein-coupled receptors (GPCRs) by phosphorylating their intracellular domains after their associated G proteins have been released and activated.
The phosphorylated serine and threonine residues act as binding sites for arrestin proteins that prevent the reassociation of the G proteins with their receptors, thereby preventing reactivation of the signaling pathway.
GRKs regulate also cellular responses independent of their kinase activity. In particular, G protein-coupled receptor kinase 2 interacts with a diverse repertoire of non-GPCR substrates.〔.〕
GRK1 is involved with Rhodopsin phosphorlylation and deactivation. Defects in GRK1 result in Oguchi disease 2.〔(【引用サイトリンク】Homo sapiens )">url=http://www.ncbi.nlm.nih.gov/gene/6011 )〕
== Types of GRKs ==


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